{4-[(tert-butoxycarbonyl)amino]phenyl}boronic acid
(4-BOC-aminophenyl)boronic acid
CAS: 380430-49-9
Molecular Formula: C11H16BNO4
{4-[(tert-butoxycarbonyl)amino]phenyl}boronic acid - Names and Identifiers
| Name | (4-BOC-aminophenyl)boronic acid |
| Synonyms | AVAC-002 (4-Boc-Aminophenyl) (4-BOC-AMINOPHENYL)BORONIC ACID (4-BOC-aminophenyl)boronic acid 4-(N-Boc-amino)phenylboronic acid 4-(N-BOC-AMINO)PHENYLBORONIC ACID 4-AMINOBENZENEBORONIC ACID, BOC PROTECTED [4-(t-Butoxycarbonylamino)phenyl]boronic acid 4-(tert-Butoxycarbonyl)aminophenylboronicacid 4-(TERT-BUTOXYCARBONYLAMINO)PHENYLBORONIC ACID {4-[(tert-butoxycarbonyl)amino]phenyl}boronic acid 4-[(tert-Butoxycarbonyl)amino]phenylboronic Acid (contains varying amounts of Anhydride) |
| CAS | 380430-49-9 |
| InChI | InChI=1/C11H16BNO4/c1-11(2,3)17-10(14)13-9-6-4-8(5-7-9)12(15)16/h4-7,15-16H,1-3H3,(H,13,14) |
| InChIKey | UBVOLHQIEQVXGM-UHFFFAOYSA-N |
{4-[(tert-butoxycarbonyl)amino]phenyl}boronic acid - Physico-chemical Properties
| Molecular Formula | C11H16BNO4 |
| Molar Mass | 237.06 |
| Density | 1.18±0.1 g/cm3(Predicted) |
| Melting Point | 199-204 °C (dec.) (lit.) |
| Solubility | soluble in Methanol |
| Appearance | Solid |
| Color | White to brown |
| pKa | 8?+-.0.17(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.53 |
| MDL | MFCD02093054 |
{4-[(tert-butoxycarbonyl)amino]phenyl}boronic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29319090 |
| Hazard Note | Irritant/Keep Cold |
| Hazard Class | IRRITANT, KEEP COLD |
{4-[(tert-butoxycarbonyl)amino]phenyl}boronic acid - Introduction
(4-BOC-aminophenyl)boronic acid is an organic compound whose chemical formula is C12H16BNO4. It is a white or off-white solid, soluble in organic solvents such as dimethyl sulfoxide and methylene chloride.
(4-BOC-aminophenyl)boronic acid is mainly used as an intermediate in organic synthesis. It can be used to synthesize drugs, pesticides and other organic compounds. Its amino and boron groups can participate in a variety of reactions, such as alcoholization, amination and coupling reactions, so it has a wide range of applications.
The method of preparing (4-BOC-aminophenyl)boronic acid generally involves a two-step reaction. First, p-nitrophenylboronic acid is reacted with a tert-butoxycarbonyl (Boc) amino group to produce an intermediate product (4-BOC-aminophenyl)boronic an acid ester. The ester is then converted to the target product (4-BOC-aminophenyl)boronic acid by a hydrolysis reaction.
Regarding safety information,(4-BOC-aminophenyl)boronic acid should be kept away from high temperature and ignition sources. When handling or handling, please take appropriate protective measures, such as wearing protective gloves and glasses. There is no specific toxicity report for this compound, but it may be irritating to the skin and eyes, so it should be thoroughly washed after contact. During use, laboratory safety regulations should be observed and waste should be properly disposed. It is best to read the product manual and safety data sheet carefully before use.
(4-BOC-aminophenyl)boronic acid is mainly used as an intermediate in organic synthesis. It can be used to synthesize drugs, pesticides and other organic compounds. Its amino and boron groups can participate in a variety of reactions, such as alcoholization, amination and coupling reactions, so it has a wide range of applications.
The method of preparing (4-BOC-aminophenyl)boronic acid generally involves a two-step reaction. First, p-nitrophenylboronic acid is reacted with a tert-butoxycarbonyl (Boc) amino group to produce an intermediate product (4-BOC-aminophenyl)boronic an acid ester. The ester is then converted to the target product (4-BOC-aminophenyl)boronic acid by a hydrolysis reaction.
Regarding safety information,(4-BOC-aminophenyl)boronic acid should be kept away from high temperature and ignition sources. When handling or handling, please take appropriate protective measures, such as wearing protective gloves and glasses. There is no specific toxicity report for this compound, but it may be irritating to the skin and eyes, so it should be thoroughly washed after contact. During use, laboratory safety regulations should be observed and waste should be properly disposed. It is best to read the product manual and safety data sheet carefully before use.
Last Update：2024-04-09 21:32:40
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